Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis

Anne Ahlmann Nielsen, Kristín Rós Kjartansdóttir, Mads Heilskov Rasmussen, Annette Balle Sørensen, Bruce Wang, Matthias Wabl, Finn Skou Pedersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice.
Original languageEnglish
JournalGene
Pages (from-to)55 - 62
Number of pages8
DOIs
Publication statusPublished - 2009
Externally publishedYes

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