A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.

Sys Zoffmann Glud, Annette Balle Sørensen, Mindaugas Andrulis, Eisaku Kondo, Bruce Wang, Randi Jessen, Laszlo Krenacs, Eva Stelkovics, Matthias Wabl, Edgar Serfling, Alois Palmetshofer, Finn Skou Pedersen

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Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
Original languageEnglish
Issue number10
Pages (from-to)3546-52
Number of pages6
Publication statusPublished - 2005
Externally publishedYes

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