Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Leukemia and Lymphoma |
| Vol/bind | 50 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1647-1660 |
| Antal sider | 14 |
| ISSN | 1042-8194 |
| DOI | |
| Status | Udgivet - 2009 |
| Udgivet eksternt | Ja |
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I: Leukemia and Lymphoma, Bind 50, Nr. 10, 2009, s. 1647-1660.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas
AU - Jørgensen, Judit Meszaros
AU - Sørensen, Flemming B
AU - Bendix, Knud
AU - Nielsen, Johan L
AU - Funder, Anette
AU - Karkkainen, Marika J
AU - Tainola, Tapio
AU - Sørensen, Annette B
AU - Pedersen, Finn S
AU - D'Amore, Francesco
PY - 2009
Y1 - 2009
N2 - The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).
AB - The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).
U2 - 10.1080/10428190903156729
DO - 10.1080/10428190903156729
M3 - Journal article
C2 - 19701853
SN - 1042-8194
VL - 50
SP - 1647
EP - 1660
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 10
ER -