Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis

Anne Ahlmann Nielsen; Kristín Rós Kjartansdóttir; Mads Heilskov Rasmussen; Annette Balle Sørensen; Bruce Wang; Matthias Wabl; Finn Skou Pedersen

doi:10.1016/j.gene.2009.04.003

Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis

Anne Ahlmann Nielsen, Kristín Rós Kjartansdóttir, Mads Heilskov Rasmussen, Annette Balle Sørensen, Bruce Wang, Matthias Wabl, Finn Skou Pedersen

Aarhus Universitet

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Udgivelsesdato: 2009-Apr-17

Originalsprog	Engelsk
Tidsskrift	Gene
Sider (fra-til)	55 - 62
Antal sider	8
DOI	https://doi.org/10.1016/j.gene.2009.04.003
Status	Udgivet - 2009
Udgivet eksternt	Ja

Bibliografisk note

AAN and KRK share first-authorship

Adgang til dokumentet

10.1016/j.gene.2009.04.003

Citationsformater

@article{ac950f3494134802be907fa78d71b375,

title = "Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis",

abstract = "Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice.",

author = "Nielsen, {Anne Ahlmann} and Kjartansd{\'o}ttir, {Krist{\'i}n R{\'o}s} and Rasmussen, {Mads Heilskov} and S{\o}rensen, {Annette Balle} and Bruce Wang and Matthias Wabl and Pedersen, {Finn Skou}",

note = "AAN and KRK share first-authorship",

year = "2009",

doi = "10.1016/j.gene.2009.04.003",

language = "English",

pages = "55 -- 62",

journal = "Gene",

issn = "1879-0038",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis

AU - Nielsen, Anne Ahlmann

AU - Kjartansdóttir, Kristín Rós

AU - Rasmussen, Mads Heilskov

AU - Sørensen, Annette Balle

AU - Wang, Bruce

AU - Wabl, Matthias

AU - Pedersen, Finn Skou

N1 - AAN and KRK share first-authorship

PY - 2009

Y1 - 2009

N2 - Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice.

AB - Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice.

U2 - 10.1016/j.gene.2009.04.003

DO - 10.1016/j.gene.2009.04.003

M3 - Journal article

C2 - 19376211

SN - 1879-0038

SP - 55

EP - 62

JO - Gene

JF - Gene

ER -