@article{5dcdc8a7c21642e386dfdb5521e8f15e,
title = "A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.",
abstract = "Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.",
author = "Glud, {Sys Zoffmann} and S{\o}rensen, {Annette Balle} and Mindaugas Andrulis and Eisaku Kondo and Bruce Wang and Randi Jessen and Laszlo Krenacs and Eva Stelkovics and Matthias Wabl and Edgar Serfling and Alois Palmetshofer and Pedersen, {Finn Skou}",
year = "2005",
doi = "10.1182/blood-2005-02-0493",
language = "English",
volume = "106",
pages = "3546--52",
journal = "Blood",
issn = "0006-4971",
publisher = "Elsevier B.V.",
number = "10",
}